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KMID : 0357920040380030133
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Korean Journal of Pathology
2004 Volume.38 No. 3 p.133 ~ p.137
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Genomic Imbalances in Ependymoma by Degenerate Oligonucleotide Primed PCR-Comparative Genomic Hybridization
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Park Sung-Hye
Kim Han-Seong
Park Sun-Hwa
Kim Min-Kyung
Kim Gi-Jin
Suh Yoen-Lim
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Abstract
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Background: The most consistent chromosomal abnormality in ependymomas, is loss of 22q (17-75%) and gain of 1q (0-50%). However, significance of this abnormality is uncertain.
Methods: Genomic imbalances in 27 Korean ependymomas, including 21 low grade ependymomas, 4 anaplastic and 2 myxopapillary ependymomas, were analyzed by degenerate oligonucleotide primed-PCR-comparative genomic hybridization.
Results: Common gains were found in 17 (63%), 20q (59%), 9q34 (41%), 15q24-qter (33%), 11q13 (30%), 12q23 (26%), 7q23-qter (26%), 16q23-qter (30%), 19 (26%), and 1q32-qter (22%). DNA amplification was identified in 12 tumors (44%). Chromosomal loss was a less common occurrence in our study, but was found in 13q (26%), 6q (19%), and 3 (11%).
Conclusion: The recurrent gains or losses of the chromosomal regions which were identified in this study provide candidate regions that may be involved in the development and progression of ependymomas.
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KEYWORD
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Ependymoma, Comparative Genomic Hydridization, Chromosomal aberration, PCR
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